SIRT7 an emerging sirtuin: deciphering newer roles.
نویسندگان
چکیده
Sirtuin7 (SIRT7) is a NAD(+)-dependent protein deacetylase which belongs to sirtuin family. Although sirtuin proteins have attracted a great deal of attention, little is known about SIRT7. SIRT7 participates in rDNA transcription in the nucleolus. However, recent reports show that SIRT7 has additional novel functions. This review summarizes all findings about SIRT7, and highlights its critical roles in cellular functions.
منابع مشابه
Molecular Pathways Molecular Pathways: Emerging Roles of Mammalian Sirtuin SIRT7 in Cancer
SIRT7belongs to the Sirtuin family ofNAD-dependent enzymes, themembers ofwhichplaydiverse roles in aging,metabolism,anddiseasebiology. IncreasedSIRT7expression isobserved inhumancancers andgrowing evidence suggests important SIRT7 functions in fundamental cellular programs with an impact on oncogenic transformation and tumor biology. SIRT7 associateswith chromatin,where it catalyzes selective d...
متن کاملMolecular pathways: emerging roles of mammalian Sirtuin SIRT7 in cancer.
SIRT7 belongs to the Sirtuin family of NAD-dependent enzymes, the members of which play diverse roles in aging, metabolism, and disease biology. Increased SIRT7 expression is observed in human cancers and growing evidence suggests important SIRT7 functions in fundamental cellular programs with an impact on oncogenic transformation and tumor biology. SIRT7 associates with chromatin, where it cat...
متن کاملHigh expression of Sirt7 served as a predictor of adverse outcome in breast cancer.
OBJECTIVE Sirt7, as one of the seven Sirtuin family members, which plays distinct roles in cancer progression, is bringing emerging attention due to its oncogenic characteristic. The expression of Sirt7 in breast cancer remained unclear, and the aim of this study was to elucidate its role in breast cancer. METHODS A total of 188 cases included in this study were immunohistochemically evaluate...
متن کاملSIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
Although SIRT7 is a member of sirtuin family proteins that are described as NAD(+)-dependent class III histone deacetylases, the intrinsic enzymatic activity of this sirtuin protein remains to be investigated and the cellular function of SIRT7 remains to be explored. Here we report that SIRT7 is an NAD(+)-dependent histone desuccinylase. We show that SIRT7 is recruited to DNA double-strand brea...
متن کاملSirtuin 7 promotes colorectal carcinoma proliferation and invasion through the inhibition of E-cadherin
Sirtuin 7 (Sirt7) is a member of the sirtuin protein family and is implicated in various carcinomas; however, the function of Sirt7 in colorectal carcinoma (CRC) remains unclear. The present study aimed to explore the biological function of Sirt7 in CRC tissues and cell lines, and to investigate the potential underlying mechanism by performing reverse transcription-quantitative polymerase chain...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
دوره 64 5 شماره
صفحات -
تاریخ انتشار 2013